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日前，发表于《Journal of Translational Internal Medicine》的综述“Senescent cells as a target for anti-aging interventions: From senolytics to immune therapies”系统梳理了靶向衰老细胞的两大前沿方向——细胞外囊泡（EVs）疗法与免疫细胞疗法，这些策略正从实验室走向临床，为. 免疫细胞可以清除衰老细胞，针对衰老细胞的免疫疗法可以对抗衰老和慢性疾病，从而延长健康寿命。 同时，Nature 杂志上的研究表示，NK细胞清除动物体内的衰老细胞，可使得寿命延长20%-30%。 相对比没有清除衰老细胞的动物，那些被清除了衰老细胞的小鼠年轻了6个月，相当于人类年轻数十年。 因此，免疫细胞疗法有望减缓衰老过程，预防和治疗与衰老相关的慢性疾病。 衰老细胞，这些本应退出历史舞台的细胞，却因种种原因在体内滞留，成为组织功能衰退和疾病发生的元凶。 它们不仅阻碍了正常细胞的更新与修复，还通过分泌有害物质扰乱周围环境，导致慢性炎症和组织损伤，最终引发一系列与年龄相关的疾病。 Here, we review how different components of the innate and adaptive immune systems, including natural killer cells, macrophages, neutrophils, dendritic cells, t cells and b cells, target. Mounting evidence indicates that immunotherapy targeting senescent cells combats ageing and chronic diseases and subsequently extends the healthy lifespan.
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