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首先，应用单细胞多组学技术揭示了小胶质细胞 (Mi_6)亚群在APOE4和衰老的AD模型组中的重要作用，详细的描述了APOE4小胶质细胞通过糖酵解等调控途径促进炎症，从而形成有利于慢性神经炎症的情况。 星形胶质细胞在糖酵解、糖异生和脂质代谢方面具有强大的酶促能力，这使得它们对脑实质内的神经元提供营养支持至关重要。 一直以来，科学家们怀疑葡萄糖可能主要由胶质细胞代谢成乳酸，后者再输出到神经元作为主要燃料支持有氧呼吸（乳酸穿梭）。 对衰老细胞的代谢分析显示，衰老细胞表现出独特的葡萄糖代谢谱，葡萄糖转运蛋白和糖酵解酶表达增加，糖酵解、TCA循环和氧化磷化活性增强，产生的乳酸量增加，总体表现为一种过度代谢状态。
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